|
Symbol Name ID |
Sh2b3
SH2B adaptor protein 3 MGI:893598 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal bleeding |
Epistaxis |
Cerebral hemorrhage |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Abnormal bone marrow cell morphology |
Abnormal megakaryocyte morphology |
Increased megakaryocyte count |
Increased micromegakaryocyte count |
Increased multinucleated megakaryocyte count |
Megakaryocyte nucleus hyperlobulation |
Myelofibrosis |
Increased hematocrit |
Abnormal hemoglobin |
Increased circulating hemoglobin concentration |
Polycythemia |
Increased red blood cell mass |
Leukocytosis |
Hemophagocytosis |
Acute leukemia |
Acute myeloid leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Arterial thrombosis |
Peripheral thrombosis |
Thromboembolism |
Venous thrombosis |
Hepatic vein thrombosis |
Abnormality of thrombocytes |
Impaired ADP-induced platelet aggregation |
Impaired collagen-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Abnormal platelet morphology |
Thrombocytosis |
Extramedullary hematopoiesis |
Myelodysplasia |
Splenomegaly |
| Disease(s) Associated with SH2B3 | ||||||||||||||||||||||||||||||||||||||
| essential thrombocythemia | ||||||||||||||||||||||||||||||||||||||
| familial erythrocytosis 1 | ||||||||||||||||||||||||||||||||||||||
| myelofibrosis |
| Mouse Phenotypes | abnormal granulocyte differentiation |
abnormal monocyte differentiation |
enlarged spleen |
spleen hyperplasia |
myeloid hyperplasia |
extramedullary hematopoiesis |
anemia |
increased bone marrow cell number |
abnormal megakaryocyte morphology |
increased megakaryocyte cell number |
increased erythroid progenitor cell number |
increased neutrophil cell number |
increased granulocyte number |
thrombocytosis |
abnormal leukocyte cell number |
decreased B cell number |
increased B cell number |
increased lymphocyte cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal hematopoietic stem cell morphology |
spleen fibrosis |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||
| Sh2b3tm1Paw/Sh2b3tm1Paw | |||||||||||||||||||||||
| Sh2b3tm1Rmp/Sh2b3tm1Rmp | |||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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